This book constitutes the refereed proceedings of the 4th IFIP TC 12 International Conference on Artificial Intelligence, IFIP AI 2015, Held as Part of WCC 2015, in Daejeon, South Korea, in October 2015. The 13 full papers presented were carefully reviewed and selected from 36 submissions. The papers are organized in topical sections on artificial intelligence techniques in biomedicine, artificial intelligence for knowledge management, computational intelligence and algorithms, and intelligent decision support systems.