Animal Models of Movement Disorders Volume I

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems. 

Part I: Generic Methods of Assessment

1. Why Can’t a Rodent Be More like a Man?: A Clinical Perspective

            Anne E. Rosser

2. Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders

            Maria Sundvik and Pertti Panula

3. Methodological Strategies to Evaluate Functional Effectors Related to Parkinson’s Disease through Application of C. elegans Models

            Kim A. Caldwell and Guy A. Caldwell

4. Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson’s Disease

            Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, and Ralph Hillman

5. Neurological Evaluation of Movement Disorders in Mice

            Simon Brooks

6. Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System

            Jenni M. Karl and Ian Q. Whishaw

7. High Throughput Mouse Phenotyping

            Sabine M. Hölter and Lisa Glasl

8. MRI of Neurological Damage in Rats and Mice

            Mathias Hoehn

9. Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research

            Nadja Van Camp, Yann Bramoullé, and Philippe Hantraye

10. Optical Approaches to Studying the Basal Ganglia

            Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress,

David L. Wokosin, and D. James Surmeier

11. Electrophysiological Analysis of Movement Disorders in Mice

            Shilpa P. Rao, Véronique M. André, Carlos Cepeda, and Michael S. Levine

Part II: Dopamine Systems

12. Genetic Models of Parkinson`s Disease

            Ralf Kühn, Daniela Vogt-Weisenhorn, and Wolfgang Wurst

13. 6-OHDA Lesion Models of Parkinson’s Disease in the Rat

            Eduardo M. Torres and Stephen B. Dunnett

14. 6-OHDA Toxin Model in Mouse

            Gaynor A. Smith and Andreas Heuer

15. Rotation in the 6-OHDA Lesioned Rat

            Stephen B. Dunnett and Eduardo M. Torres

16. Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson’s Disease Patients Cannot Move Normally

            Gordon W. Arbuthnott

17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson’s Disease and Stroke

            Sheila M. Fleming and Timothy Schallert

18. Rodent Models of L-DOPA-Induced Dyskinesia

            Hanna S. Lindgren and Emma L. Lane

19. Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson’s Disease?

            Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, and Michael W. Jakowec

20. The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus)

            Michael J. Jackson and Peter Jenner

21. Behavioral Assessment in the African Green Monkey after MPTP Administration

            D. Eugene Redmond, Jr.