Part I. The Normal Human Red Blood Cell: 1. Anemias, red cells, and the essential elements of red cell homeostasis Edward J. Benz, Jr; 2. Red cell production Benjamin L. Ebert and Anupama Narla; 3. Red cell lifespan, senescence and destruction Richard Kaufman; Part II. The Patient with Anemia: 4. The clinical approach to the patient with anemia Matt Quesenberry, Alina Huang and Fred J. Schiffman; 5. Anemias of childhood Bertil Glader and Wendy Wong; Part III. Specific Forms of Anemia; Section 1. Microcytic Anemias: 6. Iron deficiency Paula Fraenkel; 7. Sideroblastic anemias Nathan T. Connell and Edward J. Benz, Jr; 8. The thalassemia syndromes David Chui and Madeleine M. Verhovsek; Section 2. Macrocytic Anemias: 9. Megaloblastic and non-megaloblastic anemias Peter W. Marks; Section 3. Hemoglobinopathies: 10. Sickle cell syndromes Maureen Okam; 11. Structural Hemoglobinopathies Edward J. Benz, Jr; Section 4. Hemolytic Anemias: 12. Autoimmune hemolytic anemias Mark A. Murakami, Edward J. Benz, Jr and Nancy Berliner; 13. Drug-induced hemolytic anemias Oreofe O. Odejide; 14. Red cell membrane defects Patrick Gallagher; 15. Malaria Michael A. McDevitt and Richard Bucala; 16. Microangiopathic hemolytic anemia Elaine M. Majerus and J. Evan Sadler; 17. Extrinsic non-immune hemolytic anemias Pavan K. Bendapudi and Ronald P. McCaffrey; Section 5. Hypoplastic Anemias: 18. Acquired aplastic anemia and pure red cell aphasia Daria Babushok and Monica Bessler; 19. Paroxysmal nocturnal hemoglobinuria Robert A. Brodsky; 20. Congenital marrow failure syndromes Anupama Narla and Benjamin L. Ebert; 21. Anemia of chronic inflammation Satish P. Shanbhag and Cindy N. Roy; 22. Myelodysplasia Rafael Bejar and Ida Wong; Part IV. Secondary Anemias: 23. HIV and anaemia Owen Seddon, Andrew Freedman and David T. Scadden; 24. Anemia in the patient with cancer Murat Arcasoy; 25. Secondary anemias associated with hematopoietic stem cell transplantation Joseph H. Antin; 26. The anemia of aging Amanda J. Redig and Nancy Berliner; 27. Anemia in pregnancy Ariela Marshall and Jean M. Connors; 28. Anemias due to systemic diseases Ronald P. McCaffrey and Giada Bianchi; 29. Transfusion therapy for anemia Joe Sweeney; 30. Transfusion reactions Alex Ryder, Edward Snyder and David Unold; Part V. Management of Anemia: 31. Pharmacologic therapy of anemia Nicholas Short and Elisabeth Battinelli; 32. Splenectomy: indications and consequences Sophia Fircanis, Andrew Brunner and Fred J. Schiffman; Part VI. Summary: 33. Anemias: summary, conclusions, and future prospects Edward J. Benz Jr; Index.