Advances in Alzheimer's and Parkinson's Disease Insights, Progress, and Perspectives

Proceedings of the 7th International Conference on Alzheimer’s Disease and Parkinson’s Disease (ADPD), held March 9-13, 2005 in Sorrento, Italy.

The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimer’s disease and Parkinson’s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, covering topics such as immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the history, epidemiology, clinical phenomenology, diagnosis, imaging, treatment ,and future perspectives of Alzheimer’s and Parkinson’s Diseases.

Clinical Features and Treatment of Dementia Associated With Parkinson’s Disease.- Neurogenetics in Parkinson's Disease.- Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity.- Current Problems and Strategies in Motor Rehabilitation for Parkinson’s Disease.- Critical Acute Akinesia in Parkinson’s Disease Patients Concomitant with Additional Precipitating Factors Other Than Treatment Withdrawal: A Possible Lethal Complication.- Biomarkers for Early Detection of Parkinson’s Disease: An Essential Challenge.- Neurotransmitter and Neurotrophic Factor-Secreting Cell Line Grafting for the Treatment of Parkinson’s Disease.- Novel Therapeutic Target in PD: Experimental Models.- LRRK2 (Leucine-Rich Repeat Kinase 2) Gene on PARK8 Locus in Families with Parkinsonism.- Microglia Activation and Gene Expression of Cytokines in Parkinson’s Disease.- Dissecting the Biochemical Pathways Mediated by Genes Implicated in Parkinson’s Disease: Induction of DJ-1 Expression in A30P ?-Synuclein Mice.- Neuroinflammation in Early Stages of Alzheimer’s Disease and Parkinson’s Disease.- Alzheimer’s Disease, Parkinson’s Disease, and Frontotemporal Dementias: Different Manifestations of Protein Misfolding.- Role of Oxidative Insult and Neuronal Survival in Alzheimer’s and Parkinson’s Diseases.- Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer’s Disease Brain and in Brain from a Rodent Model of Familial Parkinson’s Disease: Insights into Potential Mechanisms of Neurodegeneration.- Biomarkers for Alzheimer’s Disease and Parkinson’s Disease.- Bioluminescent Imaging of Excitotoxic and Endotoxic Brain Injury in Living Mice.- Alzheimer’s Disease Neuroimaging Initiative.- Two Hits andYou’re Out? A Novel Mechanistic Hypothesis of Alzheimer Disease.- Vascular Risk Factors and Risk for Alzheimer’s Disease and Mild Cognitive Impairment: Population-Based Studies.- Cholesterol Transport and Production in Alzheimer’s Disease.- Cholesterol and A? Production: Methods for Analysis of Altered Cholesterol De Novo Synthesis.- Glycosaminoglycans and Analogs in Neurodegenerative Disorders.- Prospective Role of Glycosaminoglycans in Apoptosis Associated with Neurodegenerative Disorders.- Stem Cell Therapy in Alzheimer’s Disease.- Oral A? Vaccine Using a Recombinant Adeno-Associated Virus Vector in an Alzheimer’s Disease Mouse Model.- In Vivo Targeting of Amyloid Plaques Via Intranasal Administration of Phage Anti-?-Amyloid Antibodies.- Decreased ProBDNF: The Cause of Alzheimer’s-Associated Neurodegeneration and Cognitive Decline?.- Shift in the Balance of TRKA and ProNGF in Prodromal Alzheimer ’s Disease.- Neuroprotective Effects of Trophic Factors and Natural Products: Involvement of Multiple Intracellular Kinases.- Intraneuronal A? and Alzheimer’s Disease.- Physiological Processing of the Cellular Prion Protein and ?APP: Enzymes and Regulation.- Expression of Wnt Receptors, Frizzled, in Rat Neuronal Cells.- Cell Models of Tauopathy.- Co-expression of FTDP-17 Human Tau and GSK-3ß (or APPSW) in Transgenic Mice: Induction of Tau Polymerization and Neurodegeneration.- Enhanced Activation of NF-?B Signaling by Apolipoprotein E4.- Pleiotropic Effects of Apolipoprotein E in Dementia: Influence on Functional Genomics and Pharmacogenetics.- Up-regulation of the ?-Secretase Pathway.- Frequency and Relation of Argyrophilic Grain Disease and Thorn-Shaped Astrocytes in Alzheimer’s Disease.- Cellular Membranes as Targets in Amyloid Oligomer DiseasePathogenesis.- Ganglioside-Dependent Generation of a Seed for Alzheimer’s Disease Amyloid.- Evidence That Amyloid Pathology Progresses in a Neurotransmitter-Specific Manner.- Rationale for Glutamatergic and Cholinergic Approaches for the Treatment of Alzheimer’s Disease.- Cortical Cholinergic Lesion Causes A? Deposition: Cholinergic-Amyloid Fusion Hypothesis.- Expression of Acetylcholinesterase in Alzheimer’s Disease Brain: Role in Neuritic Dystrophy and Synaptic Scaling.- Role of b-Amyloid in the Pathophysiology of Alzheimer’s Disease and Cholinesterase Inhibition: Facing the Biological Complexity to Treat the Disease.- Dissociation Between the Potent ?-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine.- Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders.