Advances and Prospects of 3-d Metal-Based Anticancer Drug Candidates

This book reviews the potential of metallodrugs against different cancer. It summarizes the classification of metal-based anti-cancer drugs, their plausible biochemical and mechanistic pathways, combining drug strategies for hitting multiple therapeutic targets at the intracellular level, and advanced drug delivery strategies. The book covers the metallodrugs for the efficacious treatment of diverse cancerous strains and recent advances in drug delivery strategies that are used for developing these metal-based therapeutics as potent anticancer agents in vitro and in vivo. The book also covers different biophysical and analytical techniques for studying metal-ligand and metal-macromolecular interactions. The book further presents the recent examples of metallomics studies on the different types of cell death induced by metal-based anticancer drugs, especially on the three major forms of programmed cell death (PCD) in mammalian cells: apoptosis, autophagy, and regulated necrosis, alsocalled necroptosis. Lastly, the book explores the modulation of reactive oxygen species (ROS) by metallodrugs.

 Prof. Farukh Arjmand is currently working as a Professor of Chemistry at Aligarh Muslim University, Aligarh, India. Prof. Arjmand has 29 years of research and teaching experience in the area of Inorganic Chemistry, in particular, “Medicinal Inorganic Chemistry”. She is working on the Molecular design and synthesis of new metallodrug antitumor therapeutic candidates derived from bioactive ligand scaffolds with 3d transition and organotin(IV) metal ions. Her research group has isolated many promising tailored metallodrugs, and antitumor candidates, their structure elucidation was done by spectroscopic and single X-ray crystal diffraction methods, and their potential to act as anticancer chemotherapeutic agents were validated by DNA/RNA binding affinity, cleavage activity and cytotoxicity profile against a panel of human cancer cell lines and molecular docking experiments. She has published 185 research papers in journals of international repute ( with highest impact 24.83) and, contributed many articles to national/international conferences and symposiums, delivered many invited lectures and has two patents on metallic antitumor drug entities. Dr. Arjmand has 5250 citations (Scopus) to her credit with h-index 41 and i10-index 115. Prof. Arjmand has successfully guided 18 Ph.D.’s., 4 M.Phil.’s and 15 Master’s project students and has run six major research projects as Principal investigator (PI) on the design of metal-based drug candidates awarded by UGC, CSIR, and DBT, Govt. of India, and has visited many countries (China, USA, Egypt) for academic pursuits. Shehas joint research collaborations with national and international research institutes, IIT Kharagpur, IICT, Hyderabad and ACTREC, Mumbai, India, USTC, China and Institut de Physique de Rennes, France, and The Ohio State University, USA. Prof Arjmand has received many prestigious awards viz., Young Scientist, ICC,2005,  the Distinguished Women Scientist Award 2016 , ISCB , 2017, and the CRSI Bronze Medal 2019, Chemical Research Society of India, CRSI) and Outstanding Researchers Award 2022 in faculty of Science and Life science, A.M.U . Prof Arjmand was awarded  prestigious  FRSC in 2023 ( Membership number: 679931) by Royal Society of Chemistry, UK  for her contribution to chemical science and chosen as  CRSI council member in 2020 for three years . Prof Arjmand is presently serving as Co-director of APJ Abdul Kalam STEM Center for Education and Research - a collaboration of The Ohio State University, USA, and AMU, Aligarh. She completed the Academic leadership (LeAP) program, MHRD, Govt. of India at AMU, India, and OSU, USA in 2019.