Vitamin C New Biochemical and Functional Insights

Vitamin C holds a unique place in scientific and cultural history. In this book, a group of leading scientific researchers describe new insights into the myriad ways vitamin C is employed during normal physiological functioning. In addition, the text provides an extensive overview of the following: the rationale for utilizing vitamin C in the clinic, updates on recent uses of vitamin C in cancer treatment through high-dose intravenous therapies, the role vitamin C plays in the treatment of sepsis and infectious disease, management of the ways vitamin C can improve stem cell differentiation, as well as vitamin C use in other important health situations. Features Includes chapters from a team of leading international scholars Reviews the history and recent research on the functions, benefits, and uses of vitamin C Focuses special attention on the way vitamin C can be used in the treatment of cancers Discusses how vitamin C can be employed against infectious disease

Part I Overview of Vitamin C. 1. A "C Odyssey": Recommended Dietary Allowances and Optimal Health: Paradigm and Promise of Vitamin C. Part II Chemistry and Biology of Vitamin C. 2. Chemistry and Biochemistry of Vitamin C in Mammalian Systems. 3. Vitamin C Alimentation via SLC Solute Carriers. 4. Vitamin C Pharmacokinetics. 5. Ascorbate as an Enzyme Cofactor. 6. Role of Ascorbate and Dehydroascorbic Acid in Metabolism of the Cell. Part III Vitamin C and Immune Function. 7. Vitamin C in Pneumonia and Sepsis. 8. Vitamin C in Immune Cell Function. 9. Role of Vitamin C in Chronic Wound Healing. Part IV Vitamin C and Neurological Function. 10. Vitamin C in Neurological Function and Neurodegenerative Disease. 11. Vitamin C and the Brain. 12. Epigenetic Role of Vitamin C in Neurological Development and Disease.

Qi Chen, PhD, Associate Professor, Department of Pharmacology, Toxicology and Therapeutics at the University of Kansas Medical Center, Kansas, City, USA. Margareet C.M. Vissers, PhD, Research Professor, Department of Pathology and Biomedical Science at the University of Otago, Christchurch, New Zealand.