1. Basic Principles of Target Organ Toxicity Gerald M. Cohen 2. Role of Pharmacokinetics in Rationalizing Tissue Distribution J. Brian Houston 3. The Role of Metabolic Activation in Target Organ Toxicity John Caldwell, Susan A. Sangster, and J. David Sutton 4. Role of Excretion Walter G. Levine 5. Species Variation in Target Organ Toxicity J.C. Connelly and James W. Bridges 6. The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity Steven D. Aust 7. Role of Key Defense Systems in Target Organ Toxicity Toshihisa Ishikawa, Theodore P.M. Akerboom, and Helmut Sies 8. The Liver as a Target Organ for Toxicity J.A. Timbrell 9. The Nervous System as a Target Organ for Toxicity Rebecca J. Anderson, Rudy J. Richardson, and Bradley W. Schwab