Supramolecular Complexes of Oxoporphyrinogens with Organic Molecules

Macrocyclic oxoporphyrinogen molecules combine the ability to form strong supramolecular complexes with organic compounds and the ability to absorb light. These properties allow high-sensitivity colorimetric detection of acids in solution in the presence of oxoporphyrinogen. Moreover, protonated oxoporphyrinogens show various molecular dynamic processes on the millisecond timescale. This book offers deep analyses of colorimetric, binding and kinetic properties of oxoporphyrinogen-acid complexes. A detailed introduction is given for: theory of supramolecular binding and chemical kinetics; NMR spectroscopy with emphasis on multi-state chemical exchange including derivation of analytical spectral lineshapes; UV/vis spectroscopy and analysis of UV/vis spectra, using singular value decomposition (SVD). Implementation of the derived models in Mathematica is also provided. The experimental part addresses SVD analysis of UV/vis spectra illuminating the effect of protonation on various oxoporphyrinogen derivatives and explaining the colorimetric response. Furthermore, analysis of chemical exchange lineshapes offers insight into the dynamic processes present in protonated oxoporphyrinogens. The various models and techniques described in this book are widely applicable for other systems.

Introduction.- Quantitative description ofsupramolecular binding.- Nuclear magnetic resonancespectroscopy.- UV/vis spectroscopy.- Singular value decomposition.- Chromic and binding propertiesof OxP derivatives.- Dynamic processes and chemicalexchange in OxP derivatives.- Conclusion.

Václav Brezina specializes in chemical physics, focusing on NMR and UV/vis spectroscopy and analyses of the spectroscopic data with binding/kinetic models. He obtained his bachelor, master and doctoral degrees at the Charles University in Prague, Czech Republic. Václav's research on the interactions of oxoporphyrinogens with organic molecules using spectroscopic methods resulted in several publications. He undertook an internship in the National Intitute for Materials Science in Tsukuba, Japan, where he worked with Dr. Jan Labuta and Dr. Jonathan Hill. Another internship in Leipzig, Germany, in the group of prof. Frank Cichos included study of active Brownian motion in optical tweezers. Currently, Václav Brezina works as researcher at the Department of Macromolecular Physics, Charles University.