Regenerative Medicine Technology On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine

Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Introduction Microfabrication and 3-D Bioprinting of Organs-on-a-ChipPrafulla Chandra, Carlos Kengla, Sang Jin Lee Three-Dimensional Cell CultureIvy L. Mead, Colin E. Bishop Electrochemical Sensors for Organs-on-a-ChipJoyce Han-Ching Chiu, Ge-Ah Kim, Rodney Daniels MicrofluidicsPanupong Jaipan, Roger Narayan From Big Data to Predictive Analysis from in vitro SystemsAndre Kleensang, Alexandra Maertens, Thomas Hartung Lab-on-a-Chip Systems for Biomedical ApplicationsPeter Ertl From 2D Culture to 3D Microchip Models: Trachea, Bronchi/bronchiole and Lung Biomimetic Models for Disease Modeling, Drug Discovery and Personalized MedicineJoan E. Nichols,Stephanie P. Vega,Lissenya B. Argueta, Jean A. Niles, Michael Smith, Adrienne Eastaway, David Brown, Joaquin Cortiella Liver and Liver Cancer-on-a-ChipAleksander Skardal Heart-on-a-ChipMegan L. McCain Skin-on-a-ChipClaire G. Jeong Tissue Engineered Kidney ModelsErica P. Kimmerling, David L. Kaplan Body-on-a-ChipMahesh Devarasetty, Steven D. Forsythe,Thomas D. Shupe, Aleksander Skardal, Shay Soker Integrated Multi-Organoid DynamicsRan Li, Michelle B. Chen, Roger D. Kamm Cancer Metastasis-on-a-ChipRan Li, Michelle B. Chen, Roger D. Kamm Breast Cancer-on-a-ChipPierre-Alexandre Vidi, Sophie A. Lelièvre Disease ModelingHarry SalemUta Grieshammer, Kelly A. Shepard In Vivo, In Vitro And Stem Cell Technologies To Predict Human Pharmacology and ToxicologyHarry Salem Personalized MedicineElisa Cimetta, Michael Lamprecht, Sarindr Bhumiratana,Nafissa Yakubova,Nina Tandon

Sean V. Murphy, Anthony Atala