Recent Advances in the Science of Cannabis

Recent Advances in the Science of Cannabis describes progress in a variety of significant areas of cannabis science. This unique book covers topics in cultivation and secondary metabolites, aroma and chemotypes, cannabinoid structures, physiology and pharmacology, as well as the development of unique topical products. State-of-the-art analytical methods and instrumentation are covered, including current developments in mass spectrometry and chromatography, as well as microbial testing. Given the popularity of smoking and vaporizing cannabis, the chemistry of vaping cannabinoid and terpene concentrates is also presented, along with emerging regulatory issues.  Key Features: A guide to emerging modern cannabis technology in a dynamic regulatory climate and appealing to both novices and specialists. Building upon pioneering studies of terpene and cannabinoid chemistry, this distinctive volume describes current best practices, technological breakthroughs and historical context. Written by researchers in industry and academia, a greater understanding of the risks of exposure to emissions from vaping or dabbing cannabis concentrates is provided here. A selection of the book content reviewing Thermal Degradation of Cannabinoids and Cannabis Terpenes has been included in “Hot 2021” RSC Advances.

Contents Preface......................................................................................................................vii Editors........................................................................................................................ix Contributors...............................................................................................................xi Chapter 1 Cultivation Stress Techniques and the Production of Secondary Metabolites in Cannabis sativa.............................................................1 Callie Seaman Chapter 2 Aroma in Cannabis: A Foundation for Chemotype Classification..... 31 John S. Abrams, William J. T. Ellyson, Victor J. Gomez, and Jean L. Talleyrand Chapter 3 Cannabinoid Chemistry of Cannabis.................................................. 49 David Dawson and Markus Roggen Chapter 4 Use of Mass Spectrometry for the Analysis of Cannabis sativa spp......................................................................................... 79 Allegra Leghissa and Zacariah L. Hildenbrand Chapter 5 New Trends in the Analysis of Cannabis-Based Products................ 111 Laura Mercolini, Roberto Mandrioli and Michele Protti Chapter 6 Cannabis Microbial Testing: Methodologies and Considerations..... 131 Kyle Boyar Chapter 7 Cannabis Extract Formulations and Devices.................................... 161 Brad Douglass and Robert M. Strongin Chapter 8 Transdermal Delivery........................................................................ 193 Carolyn Burek, Jessica Painter, and Monica Vialpando Chapter 9 Thermal Degradation of Cannabinoids and Cannabis Terpenes: A Review........................................................................................... 215 Jiries Meehan-Atrash and Robert M. Strongin Chapter 10 Cannabis Pharmacokinetics and Pharmacodynamics...................... 235 Ted W. Simon Index....................................................................................................................... 267

Robert M. Strongin is a Professor of Organic Chemistry at Portland State University. He has studied the chemistry of vaping since 2013. He has been interested in determining how flavorings, including terpenes and other vape constituents, react and degrade when heated and aerosolized. In 2017 he began to investigate cannabis vaping and published the first peer-reviewed reports on the specific byproducts formed when dabbing terpenes, and, more recently, on the reactions and products that form upon vaping and dabbing concentrated cannabis oil mixtures. Dr. Strongin runs an internationally recognized research program, is a founder of two biotech startup companies, and is known for his contributions to STEM education. In addition to tobacco control and cannabis science, he is an expert in the field of biosensors and targeted molecular probes for imaging cancer tissue. Monica Vialpando is a pharmaceutically trained product development scientist, specializing in the formulation of poorly water-soluble drugs. As founder and CEO of Via Innovations, a bespoke product development company, she integrates this background with plant-based medicines to create fit-for-purpose designed products. In addition to her entrepreneurial endeavors, she is active in education and thought leadership and often focuses on cannabis-based strategies to support women’s health, and is a scientific advisor to multiple organizations. With a passion for diversity and global connection, Dr. Vialpando’s reach extends beyond typical barriers to collaborate with international experts and companies. She also leverages this throughout her company to design their differentiated products through the integration of plantbased medicines, science, technology, and art. Jiries Meehan-Atrash graduated from the State University of New York at New Paltz with a Bachelor of Science in Chemistry in 2014 and in 2021 earned his PhD in Chemistry from Portland State University after studying e-cigarette aerosol chemistry and analytical methods under the mentorship of Dr. Robert M. Strongin. Jiries is currently a postdoctoral fellow at the University of Rochester Medical Center in the laboratory of Dr. Irfan Rahman.