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gadamasetti kumar (curatore); braish tamim (curatore) - process chemistry in the pharmaceutical industry, volume 2

Process Chemistry in the Pharmaceutical Industry, Volume 2 Challenges in an Ever Changing Climate

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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

CRC Press

Pubblicazione: 12/2007
Edizione: 1° edizione





Trama

Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-date reference offers a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs.




Note Editore

As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic, physical, and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis, clinical trials, and commercializing drug candidates. The second installment in this progressive series, this volumereviews the latest breakthroughs to advance process chemistry, including asymmetric synthesis, crystallization, morphology, enzymatic intervention, green chemistry, macromolecules (monoclonal antibodies, biological molecules, polymers), enantioselectivity, organometallic chemistry, process analytical tools, chemical engineering controls, regulatory compliance, and outsourcing/globalization. It explores new approaches to synthetic processes, examines the latest safety methods and experiment design, and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy, ease of synthesis, instrumentation, automization, quality control, cost considerations, green practices, and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions byreputed scientists, technologists, engineers, and professors from leading academic institutions, such as the Imperial College, UK, the University of Tokyo, ETH, Switzerland, the International University at Bermen, Germany, and the University of Connecticut, USA, and from principal pharmaceutical companies that include Merck, Bristol Myers Squibb, Pfizer, Novartis, Eli Lilly, Astrazeneca and DSM.




Sommario

Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever-Changing Climate—An Overview; K. Gadamasetti Emerging Trends in Process Chemistry; T.F. Braish, F. De Knaep, and K. Gadamasetti Varenicline: Discovery Synthesis and Process Chemistry Developments; J.W. Coe, H.A. Watson Jr., and R.A. Singer The SUTENT® Story; R. Vaidyanathan An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist; C. Savarin, J. Chung, J.A. Murry, R.J. Cvetovich, C. McWilliams, D. Hughes, J. Amato, G. Boice, K. Conrad, E. Corley, R. Reamer, and L. DiMichele Process Research and Development of LY414197, a 5HT2B Antagonist; A. Borghese and A. Merschaert To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant; H. J.Federsel and A. Sveno Chiral Amine Synthesis—Strategies, Examples, and Limitations; T.C. Nugent Unnatural Amino Acids; D.J. Ager The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862; C.P. Ashcroft, S. Challenger, A.M. Derrick, Y. Hajikarimian, and N.M. Thomson Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals; T. Norris The Lithium–Halogen Exchange Reaction in Process Chemistry; W.F. Bailey and T.L. Rathman Oxetan-3-one: Chemistry and Synthesis; G. Wuitschik, E.M. Carreira, M. Rogers-Evans, and K. Müller Well-Defined (NHC)Pd (II) Complexes and Their Use in C–C and C–N Bond-Forming Reactions; O. Navarro and S.P. Nolan Toward Truly Efficient Organic Reactions in Water; C. Ogawa and S. Kobayashi The Chemical Development of the Commercial Route to Sildenafil Citrate; P.J. Dunn Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds; R.L. Hanson Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients—From Art to Science; D. Wieckhusen In Situ Mid-Infrared Spectroscopy for Process Development; D.A. Conlon, W. Izzo, J. Christopher McWilliams, R.A. Reamer, F. Xu, and P. Collins Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Reaction; J.C. McWilliams and R.A. Reamer Development of Efficient One-Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism; F. Xu Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend®); D.A. Conlon, W. Izzo, and P. Collins Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals—Promise, Practice, and Challenges; C.A. Mojica and L. St. Pierre-Berry PEGylation of Biological Macromolecules; J.J. Buckley, R.F. Finn, J. Mo, L.A. Bass, and S.V. Ho Microwave Technology in Process Optimization; F. Mavandadi Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture; S. Casnocha, R. Fedechko, P. Mensah, J. Mott, and S. Nema Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps; N. Zotova, S.P. Mathew, H. Iwamura, and D.G. Blackmond Trends in Outsourcing; J. Lu and I. Shinkai Sourcing Pharmaceutical Products in China and India; D. Robins and S. Hannon Index




Autore

Kumar Gadamasetti, Tamim Braish










Altre Informazioni

ISBN:

9780849390517

Condizione: Nuovo
Dimensioni: 10 x 7 in Ø 2.40 lb
Formato: Copertina rigida
Illustration Notes:381 b/w images and 58 tables
Pagine Arabe: 538


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