Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV Theory and Instrumentation

Reflecting the substantial increase in popularity of quadrupole ion traps and Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers, Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV: Theory and Instrumentation explores the historical origins of the latest advances in this expanding field. It covers new methods for trapping ions, such as the Orbitrap™, the digital ion trap (DIT), the rectilinear ion trap (RIT), and the toroidal ion trap; the development and application of the quadrupole ion trap (QIT) and the quadrupole linear ion trap (LIT); and the introduction of high-field asymmetric waveform ion mobility spectrometry (FAIMS). After a combined appreciation and historical survey of mass spectrometry and a discussion of how improved capabilities for microfabrication have led to interest in arrays of ion traps, the book examines the theory and practice of the Orbitrap mass analyzer, the rectangular waveform-driven DIT mass spectrometer, FAIMS, and ion traps with circular geometries. It next discusses ion accumulation for increasing sensitivity in FT-ICR spectrometry, a radio frequency-only-mode event for Penning traps in FT MS, and an FT operating mode applied to a 3D-QIT. The text then presents three behavioral aspects of quadrupole rod sets, before illustrating the development of the 3D-QIT in recent years. The final chapters explore photodissociation in ion traps and the chemical and photochemical studies of metal dication complexes in a 3D-QIT. In this volume that spans twenty-one chapters, a stellar panel of leading experts and up-and-coming researchers presents a cohesive, global, and up-to-date view of the practical aspects of using trapped ion devices. A companion to Volume V: Applications of Ion Trapping Devices, the book authoritatively covers the theory involved as well as the instrumentation currently used in this dynamic field.

FundamentalsAn Appreciation and Historical Survey of Mass Spectrometry, Raymond E. March and John F.J. ToddIon Traps for Miniature, Multiplexed, and Soft-Landing Technologies, Scott A. Smith, Christopher C. Mulligan, Qingyu Song, Robert J. Noll, R. Graham Cooks, and Zheng Ouyang New Ion Trapping TechniquesTheory and Practice of the Orbitrap Mass Analyzer, Alexander MakarovRectangular Waveform Driven Digital Ion Trap (DIT) Mass Spectrometer: Theory and Applications, Francesco L. Brancia and Li DingHigh-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS), Randall W. PurvesIon Traps with Circular Geometries, Daniel E. Austin and Stephen A. Lammert Fourier Transform Mass SpectrometryIon Accumulation Approaches for Increasing Sensitivity and Dynamic Range in the Analysis of Complex Samples, Mikhail E. Belov, Yehia M. Ibrahim, and Richard D. SmithRadio Frequency-Only-Mode Event and Trap Compensation in Penning Fourier Transform Mass Spectrometry, Adam M. Brustkern, Don L. Rempel, and Michael L. GrossA Fourier Transform Operating Mode Applied to a Three-Dimensional Quadrupole Ion Trap, Y. Zerega, J. Andre, M. Carette, A. Janulyte, and C. Reynard Quadrupole Rod SetsTrapping and Processing Ions in Radio Frequency Ion Guides, Bruce A. Thomson, Igor V. Chernushevich, and Alexandre V. LobodaLinear Ion Trap Mass Spectrometry with Mass-Selective Axial Ejection, James W. HagerAxially Resonant Excitation Linear Ion Trap (AREX LIT), Yuichiro Hashimoto 3D-Quadrupole Ion Trap Mass SpectrometryAn Examination of the Physics of the High-Capacity Trap (HCT), Desmond A. Kaplan, Ralf Hartmer, Andreas Brekenfeld, Jochen Franzen, and Michael SchubertElectrically Induced Nonlinear Ion Traps, Gregory J. Wells and August A. SpechtFragmentation Techniques for Protein Ions Using Various Types of Ion Trap, Jochen Franzen and Karl Peter WanczekUnraveling the Structural Details of the Glycoproteome by Ion Trap Mass Spectrometry, Vernon Reinhold, David J. Ashline, and Hailong ZhangCollisional Cooling in the Quadrupole Ion Trap Mass Spectrometer (QITMS), Philip M. Remes and Gary L. Glish"Pressure Tailoring" for Improved Ion Trap Performance, Dodge L. Baluya and Richard A. YostA Quadrupole Ion Trap/Time-of-Flight Mass Spectrometer Combined with a Vacuum Matrix-Assisted Laser Desorption Ionization Source, Dimitris Papanastasiou, Omar Belgacem, Helen Montgomery, Mikhail Sudakov, and Emmanuel Raptakis Photochemistry of Trapped IonsPhotodissociation in Ion Traps, Jennifer S. BrodbeltPhotochemical Studies of Metal Dication Complexes in an Ion Trap, Guohua Wu, Hamish Stewart, and Anthony J. Stace Index

Raymond E. March is Professor Emeritus of Chemistry at Trent University in Peterborough, Ontario, Canada. John F.J. Todd is Emeritus Professor of Mass Spectroscopy at the University of Kent in Canterbury, UK.