Olfaction and the Brain

Olfaction and its relation to mental health is an area of growing interest, evidenced by the 2004 Nobel Prize in Physiology or Medicine being awarded for discoveries relating to odorant receptors and the organization of the olfactory system. Olfaction is of particular interest to specialists seeking a fuller understanding of schizophrenia. Clear deficits in the sense of smell could predict schizophrenia in apparently unaffected individuals. In this book, first published in 2006, Warrick Brewer and his team of experts set out our understanding of olfaction and mental health, relating it to broader principles of neural development and processing as a foundation for understanding psychopathology. The neuropathological, neuropsychological and neuropsychiatric aspects of olfactory function and dysfunction are all covered (drawing on neuroimaging techniques where appropriate), and indications for future research and applications are discussed.

Foreword Peter Doherty; Preface Warrick Brewer, David Castle and Christos Pantelis; Part I. Neurology, Neurophysiology and Neuropsychology - Olfactory Clues to Brain Development and Disorder: 1. Structure and function of the olfactory system Alan Mackay-Sim and Jean-Pierre Royet; 2. Olfaction and the temporal lobes Jelena Djordjevic and Marilyn Jones-Gotman; 3. Role of the insula in smell and disgust Mary Phillips and Maike Heining; 4. Memory of smells past Mikisha Doop, Christine Mohr, Bradley Folley, Warrick Brewer and Sohee Park; 5. Olfactory neurogenesis: a window on brain development François Féron, Richard McCurdy, John McGrath, Alan Mackay-Sim; 6. Olfactory processing and brain maturation Warrick Brewer, Stephen Wood, Cinzia De Luca and Christos Pantelis; 7. Probing behavior regulation: role for olfaction in addiction? Dan Lubman, Warrick Brewer and Murat Yucel; Part II. Social Functioning: Role of Evolution, Genetics and Gender: 8. Primate evolution: anatomy and olfaction Timothy Smith and James Rossie; 9. Genetics and family influences on olfaction Raquelle Mesholam-Gately and Larry Seidman; 10. Sex differences and olfactory function Kim Good and Lili Kopala; 11. Role of pheromones and chemistry: lessons from comparative anatomy Michael Stoddart; 12. The impact of olfaction on human social functioning Dolores Malaspina, Cheryl Corcoran and Nora Goudsmit; Part III. Assessment and Disorders of Olfaction: 13. Assessment of olfaction Richard Doty; 14. Olfaction and neuropsychiatric disorders: what can deficits tell us? Christos Pantelis and Warrick Brewer; 15. Olfaction in Parkinsonian syndromes: early prediction? Christopher Hawkes; 16. Olfaction in psychosis Paul Moberg and Bruce Turestsky; 17. Olfactory hallucinations Dennis Velakoulis; 18. Delusions of body malodour: the olfactory reference syndrome Katherine Phillips, Craig Gunderson, Uschi Gruber and David Castle.

The 2004 Nobel Prize in Physiology or Medicine was awarded for reseach on the olfactory system. This 2006 book sets out our understanding of olfaction and mental health, including where it may take us in the future. All aspects of olfactory function and dysfunction are covered.