Microneedling in Clinical Practice

Microneedles provide an artificial pathway across the skin barrier for medical and cosmetic applications. This technology has seen a significant increase in popularity over the past years; as an example, the use of multiple small needles mounted on a roller to pierce the skin, prompting it to stimulate collagen production, has undergone a resurgence of interest as an adjunctive procedure for a number of skin disorders. This monograph draws together what is known about how to integrate microneedle technology into clinical dermatologic practice.

List of Contributors Microneedles and Trandermal Transport Ashley Clarke and Raja Sivamani Skin perforation and solid microneedles Michael L Crichton and Mark Kendall Dissolvable and Coated Microneedle Arrays: Design, Fabrication, Materials, and Administration Methods Emrullah Korkmaz and O. Burak Ozdoganlar Hollow Microneedles Iman Mansoor and Boris Stoeber Microneedles vs other transdermal technologies Yeakuty Jhanker, James H.N. Tran, Tarl W. Prow, and Heather A.E. Benson Combination of Microneedles with other methods Sahitya Katikaneni Medical Applications of Microneedles Samantha Tran and Raja Sivamani Therapeutic drug and biomolecule monitoring potential for microneedle technologies Sahan A. Ranamukhaarachchi and Urs O. Häfeli Commercialized Microneedles Kang Ju Lee, Seung Hyun Park, Ji Yong Lee, and Won Hyoung Ryu Considerations for Clinical Trials Involving Microneedle Devices Janet Tamada Cosmetic Applications Aunna Pourang and Kourosh Beroukhim Dermatotoxicology of Microneedles in Man John Havens Cary, Becky S. Li, and Howard I. Maibach Index

Boris Stoeber, PEng, PhD is Professor, Mechanical Engineering and Electrical and Computer Engineering, Research Chair in Microfluidics and Sensing Technology, Faculty of Applied Science, University of British Columbia, Vancouver Raja K Sivamani, MD, MS (Bioengineering), AP is Ayurvedic Practitioner, Pacific Skin Institute; Adjunct Associate Professor of Clinical Dermatology, Director of Clinical Research, University of California, Davis; Associate Professor of Dermatology, California Northstate University, College of Medicine; and Adjunct Assistant Professor, Co-Director of Microbiome Labs Research Initiative, Department of Biological Sciences, California State University, Sacramento Howard I. Maibach, MD is Professor, Dermatology, School of Medicine, University of California at San Francisco