This book constitutes the thoroughly refereed post-proceedings of the 21st International Conference on Inductive Logic Programming, ILP 2011, held in Windsor Great Park, UK, in July/August 2011. The 24 revised full papers were carefully reviewed and selected from 66 submissions. Also included are five extended abstracts and three invited talks. The papers represent the diversity and vitality in present ILP research including ILP theory, implementations, probabilistic ILP, biological applications, sub-group discovery, grammatical inference, relational kernels, learning of Petri nets, spatial learning, graph-based learning, and learning of action models.