Gene-Based Therapies for Cancer

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

RNAi: A New Paradigm in Cancer Gene Therapy.- Gene-Based Therapy for Cancer: Brain Tumors.- Gene Therapy of Prostate Cancer.- siRNA Versus shRNA for Personalized Cancer Therapy: Mechanisms and Applications.- Tumor Suppressor Gene Therapy.- Targeted Oncolytic Adenovirus for Human Cancer Therapy: Gene-Based Therapies for Cancer.- Gene Therapy for Malignant Pleural Mesothelioma.- Mesenchymal Stem/Stromal Cells as Cellular Vehicles for Tumor Targeting.- Retargeting Adenovirus for Cancer Gene Therapy.- Lentiviruses: Vectors for Cancer Gene Therapy.- Interleukin-24 Gene Therapy for Melanoma.- Herpes Simplex Virus 1 for Cancer Therapy.- Telomerase as a Target for Cancer Therapeutics.- Gene Therapy for Sarcoma.