Colonic Diverticular Disease

The book provides up-to-date information on all aspects of colonic diverticular disease, particularly common in Western countries. Most people suffering from it remain asymptomatic, while about 20% develop symptoms without complications, experiencing the so-called "Symptomatic Non-Complicated Diverticular Disease" (SUDD). 10-25% of this last group eventually  develop diverticulitis, with or without complications. The incidence of diverticulitis and diverticular colon disease is increasing worldwide, and is becoming a significant burden for national health systems in terms of direct and indirect costs, also because its prevalence increases with age. Unfortunately, the disease pathogenesis is relatively unknown and several aetiological factors may play a role in its onset.

Written by experts in the field, the volume will be a unique and valuable resource for all clinicians, residents, and physicians involved in the management of this disease.

Part 1 Epidemiology: 1- history of the disease.- 2 -anatomy of the colon and colonic diverticula.- 3- epidemiology of diverticular disease.- 4 -economic burden of diverticular disease.- 5 colorectal cancer and diverticular disease.- 6 myth and evidence.- - Part 2: Etiopatogenesis: 7- motility in diverticular disease.- 8- enteric nervous system and diverticular disease.- 9 - hypersensibility, visceral perception.- 10- role of mucosal inflammation.- 11- molecular basis of diverticular disease.- 12 - the colonic fibrosis.- 13 - genetic aspects.- 14 -the microbiome and diverticular disease.- 15 - obesity and diverticular disease.- 16- lifestyles and diverticular disease.- Part 3 - Clinical spectrum of diverticular disease: 17 - symptomatic uncomplicated diverticular disease (SUDD).- 18 - uncomplicated diverticulitis.- 19 - complicated diverticulitis.- 20 – bleeding.- 21 - segmental colitis associated diverticular disease (SCAD).- 22 - diverticular disease in the immunocompromised patient.- Part 4: Diagnostic approach: 23- investigation of patient with suspect diverticular disease.- 24- laboratory in diverticular disease.- 25- imaging of diverticular disease.- 26- colonoscopy in diverticular disease.- 27- DICA classification.- 28- complicated forms of diverticular disease.- 29- differential diagnosis in diverticular disease.- 30- pathology of diverticular disease.- Part 5: Differential diagnosis: 31- irritable bowel syndrome vs SUDD.- 32- SIBO and diverticular disease.- 33- segmental colitis associated to diverticulosis vs IBD.- Part 6: Medical treatment: 34- prevention of diverticular disease.- 35- nutritional approach to diverticular disease.- 36- fibers.- 37- probiotics.- 38- aminosalicylates 39- antibiotics.- 40- medical treatment of acute diverticulitis.- 41- treatment of recurrent diverticulitis.- 42- treatment of non-complicated diverticular disease.- 43- evidence-based medical treatment in preventing acute diverticulitis recurrence.- - Part 7 Endoscopic and surgical treatment: 44 - current management of diverticular bleeding.- 45- surgical treatment of acute diverticulitis.- 46- evidence based surgical treatment of diverticular disease.- 47- laparoscopic surgery for Hinchey III and IV acute diverticulitis.- 48- open surgery for Hinchey III and IV acute diverticulitis.- 49-robotic surgery for diverticular disease.- 50 - colostomy in diverticular disease.- 51 - symptoms recurrence and management after surgery.

Mauro Bafutto, MD PhD, is currently an Associate Professor of Gastroenterology, School of Medicine, Universidade Federal de Goiás, Goiânia, Brazil. His main research interests are: diverticular disease of the colon; inflammatory bowel disease; inflammation. He has published 50 articles in peer reviewed journals and 35 book chapters. He has presented 180 lectures at national and international congresses.

Enio Chaves Oliveira, MD PhD,  Chief of the Digestive System Division, Hospital da Clinicas, Universidade Federal de Goiás, Goiânia, Brazil,  is Associate Professor of Surgery, School of Medicine, Universidade Federal de Goiás, Goiânia, Brazil, and Professor at the Post-Graduated Health Science Programme at the same university. His research interests focus on  diverticular disease of the colon, enteric nervous system, and inflammation. He authored 80 peer-reviewed articles and 25 book chapters. He has delivered more than 150 lectures in national and international congresses.