Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids

This book introduces the principles of polymer science and chemistry and the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. With contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.

Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases.Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.

Structures, Properties, and Characterization of Biomaterials, A. Nan and H. GhandehariStep-Reaction and Ring-Opening Polymerization, R.P. Pawar and A.J. DombCopolymer, Block Copolymers Stimuli-Sensitive Polymers, K.M. Huh, S.C. Lee, Y.J. and K. ParkPolymer Solution Properties, Polymer Networks, Micelles, Dendrimers, Hydrogels, T. Ooya and K. ParkProtein Conjugation, Cross-linking and PEGylation, K.D. HindsComplement Activation by Injectable Polymeric Carriers, C. Passirani and J-P. BenoitBiological Membranes and Barriers, Y. Omidi and M. GumbletonPharmacokinetics of Proteins and Nucleic Acid Drugs, B. MeibohmIn Vivo Fate of Polymeric GENE Carriers, D. FischerSubcellular Fate of sProteins and Nucleic Acids, D. OupickyStability of Proteins and Nucleic Acids, Z-R. LuFormulation, Stability and Characterization of Protein and Peptide Drugs, S. FrokjaerMicro- and Nanoparticulate Polymeric Delivery Systems for Nucleic Acid-based Medicines, S.P. Barman and M.L. HedleyLiposomal Delivery Systems of Proteins and Peptide Drugs, V. TorchillinMechanisms of Cellular Drug Resistance and Strategies to Overcome It, T. MinkoTransporters as Molecular Targets for Drug Delivery and Disposition, I. TamaiProtein Transduction Domains as a Novel Tool for Delivery of Protein, Peptides and Nucleic Acids, R.L. Pastori, M.M. Ribeiro, D. Klein, and C. RicordiIntroduction to Therapeutic Nucleic Acids, A. G. SchätzleinAntisense and Antigene Oligonucleotide Delivery, R.I. Mahato, Z. Ye, and R.V. GuntakaArtificial Nucleic Acid Chaperones, A. MaruyamaBasic Components of Plasmid-Based Gene Expression Systems, M. Lee and S.W. KimDesign Elements of Polymeric Gene Carriers, J.S. Choi and J.-S. Park