An Introduction to Toxicogenomics

Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies.Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

FUNDAMENTALS OF EXPRESSION PROFILING ANALYSISPreparation and Utilization of Microarrays, Sophie Wildsmith and Fiona SpenceComparative Studies Using cDNA versus Oligonucleotide Arrays, Jiang Li and Jeffrey A. JohnsonQuality Control of Expression Profiling Data, Andrew Hill and Maryann WhitleyAn Introduction to Cluster Analysis, Frederick Immermann and Youping HuangEXPRESSION PROFILING AND TOXICOLOGY: THE ADVENT OF TOXICOGENOMICSTranscriptional Profiling in Toxicology, Julia Scheel, Marie-Charlotte von Brevern, and Thorsten StorckMODEL SYSTEMS IN TOXICOGENOMIC STUDIESMicroarrays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers, David Gerhold, Jian Xu, and Thomas RushmoreCharacterization of Hepatocytes and Their Use as a Model System in Toxicogenomics, Thomas K. Baker, Marnie A. Higgins, Mark. A. Carfagna, and Timothy P. RyanMECHANISTIC TOXICOGENOMICSMolecular Signatures of Dioxin Toxicity, J. Kevin Kerzee, Craig R. Tomlinson, Jennifer L. Marlowe, and Alvaro PugaToxicogenomic Dissection of the Antioxidant Response, Jiang Li and Jeffrey A. JohnsonAn Overview of Mechanistic Toxicogenomic Studies, Julia Scheel, Marie-Charlotte von Brevern, and Thorsten StorckPREDICTIVE TOXICOGENOMICSGene Expression Profile Databases in Toxicity Testing, Robert T. Dunn II and Kyle L. KolajaPredictive Toxicogenomics, Mark W. Porter, Arthur L. Castle, Michael S. Orr, and Donna L. MendrickUnsupervised Hierarchical Clustering of Toxicants, Jeffrey F. Waring and Roger G. UlrichToxicogenomic Analysis in Clinical Phamacogenomic Studies, Michael E. BurczynskiTHE FUTURE OF TOXICOGENOMICSThe Future of Toxicogenomics, John C. Rockett

Michael E. Burczynski