Acute Respiratory Distress Syndrome, Second Edition

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS). Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS. Highlights include: the definition, epidemiology, pathology, and pathogenesis of ARDS complications such as transfusion-related injury, and endothelium and vascular dysfunction the long-term outcomes of ARDS host defense and infection the latest developments in ARDS therapy: glucocorticoid therapy, surfactant therapy, mechanical ventilation, and mesenchymal stem cells predictive factors: gene expression profiling and biomarkers, and chemokines and cytokines advances in management strategies: fluid management, non-pulmonary and non-sepsis management, and glucose control

Definitions and Clinical Risk FactorsMarc Moss and B. Taylor ThompsonEpidemiology of Acute Lung Injury: A Public Health PerspectiveGordon D. Rubenfeld and Margaret J. NeffRadiographic Findings of the Acute Respiratory Distress SyndromePhilip C. Goodman and Desir´ee M. Qui˜nonesPulmonary Pathology of ARDS: Diffuse Alveolar DamageLester Kobzik and Lynette ShollPathogenesis of Acute Lung Injury: Experimental StudiesRebecca M. Baron and Mark A. PerrellaPathogenesis of Acute Lung Injury: Clinical StudiesBenedict C. Creagh-Brown and Timothy W. EvansApoptosis in the Pathogenesis and Resolution of Acute Lung InjuryGustavo Matute-Bello and Thomas R. MartinPathogenesis of Ventilator-Induced Lung InjuryFranco Valenza, James A. Frank, Yumiko Imai, and Arthur S. SlutskySepsis in the Acute Respiratory Distress Syndrome: Treatment ImplicationsArthur P. Wheeler and Todd W. RiceTransfusion-Related Acute Lung InjuryMark R. Looney and Ognjen GajicMechanisms of Fibroproliferation in Acute Lung InjuryDanielle Morse and Carol Feghali-BostwickCurrent Approaches and Recent Advances in the Genetic Epidemiology of Acute Lung Injury/Acute Respiratory Distress SyndromeMichelle NG Gong and David C. ChristianiGene Expression Profiling and Biomarkers in ARDSJudie Howrylak and Augustine M. K. ChoiResolution of Alveolar Edema: Mechanisms and Relationship to Clinical Acute Lung InjuryLorraine B. Ware and Michael A. MatthayLung Vascular Dysfunction and Repair in Acute Lung Injury: Role of the Endothelial CytoskeletonGabriel D. Lang, Eddie T. Chiang and Joe G. N. GarciaSurfactant Therapy in the Acute Respiratory Distress SyndromeRoger G. Spragg and James F. LewisProne Position in ARDSAntonio Anzueto and Luciano GattinoniMechanical Ventilation in the Acute Respiratory Distress SyndromeRoy G. Brower and Laurent BrochardFluid Therapy and HemodynamicMonitoring in Acute Lung InjuryCarolyn S. Calfee, Naveen Gupta, and Michael A. MatthayPathogenesis of Sepsis and Sepsis-Induced Acute Lung InjuryEstelle S. Harris, Matthew T. Rondina, Hansj¨org Schwertz, Andrew S. Weyrich, and Guy A. ZimmermanCell-Based Therapy for Acute Lung Injury and Acute Respiratory Distress SyndromeNaveen Gupta, Jae-Woo Lee, and Michael A. MatthayChemokines and Cytokines in ARDSMichael P. Keane, Emer Kelly, and Robert M. Strieter