Investigations of Early Nutrition Effects on Long-Term Health

TRAMA

This volume contains several reviews in the field as well as the step-by-step use of targeted and global approaches within the areas of genomics, epigenetics, proteomics, transcriptomics and metabolomics which aim to address this dilemma and to help pinpoint new treatment strategies. Chapters detail the generation of several models and methods for assessing health and provide researchers potential approaches for reversing or minimizing effects of disease. In addition, important information on disease mechanisms is provided, as each method is described in the context of a specific disease or therapeutic area. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Investigations of Early Nutrition Effects on Long-Term Health: Methods and Applications aim is to provide insights into the latest ideas and technologies .enabling progress in this field.

SOMMARIO

Part I: Reviews 1.                  Nutritional Programming Effects on Development of Metabolic Disorders in Later Life Thomas Prates Ong and Paul C. Guest   2.                  Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease Leslie Myatt and Kent L Thornburg   3.                  Developmental Origins of Stress and Psychiatric Disorders Francesca L Guest and Paul C. Guest   4.                  Proteomic Studies of Psychiatric Disorders Paul C. Guest   5.                  Developmental Origins of Breast Cancer: A Paternal Perspective Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke, Sonia de Assis, and Thomas Prates Ong   6.                  Point-of-care Testing and Personalized Medicine for Metabolic Disorders Francesca L. Guest and Paul C. Guest   7.                  Pregnancy and Lactation a Window of Opportunity to Improve Individual Health Guadalupe L. Rodríguez-González, Diana C Castro-Rodríguez, and Elena Zambrano   8.                  Utility of Small Animal Models of Developmental Programming Clare M Reynolds and Mark H Vickers   Part II: Protocols 9.                  Generation of Maternal Obesity Models in Studies of Developmental Programming in Rodents Paul D Taylor, Phillippa A Matthews, Imran Y Khan, Douglas Rees, NozomiItani, Lucilla Poston   10.              Generation of the Maternal Low Protein Rat Model for Studies of Metabolic Disorders Dan Ma, Susan E. Ozanne, and Paul C. Guest   11.              Investigation of Paternal Programming of Breast Cancer Risk in Female Offspring in Rodent Models Camile Castilho Fontelles, Raquel Santana da Cruz, Leena Hilakivi-Clarke, Sonia de Assis, and Thomas Prates Ong   12.              Studies of Isolated Peripheral Blood Cells as a Model of Immune Dysfunction Hassan Rahmoune and Paul C. Guest   13.              Studies of a Neuronal Cell Line as a Model of Psychiatric Disorders Keiko Iwata   14.              Assessment of Placental Transport Function in Studies of Disease Programming Amanda N. Sferruzzi-Perri   15.              Assessment of Fatty Liver in Models of Disease Programming Kimberley D Bruce and Karen R Jonscher   16.              Capillary Blood Sampling from the Finger Kieron Rooney   17.              Physical Activity Assessment in Clinical Studies of Substance use Disorder Rhiannon Dowla, Bridin Murnion, Kia Roberts, Jonathan Freeston, and Kieron Rooney   18.              Cardiopulmonary Exercise Testing Derek Tran   19.              Cardiovascular Assessment in Human Research Marjan Mosalman Haghighi and Julian Ayer   20.              Nutritional Programming Effects on the Immune System Donald B. Palmer   21.              Small RNA Sequencing - A Technique for miRNA Profiling Lucas Carminatti Pantaleão and Susan E. Ozanne   22.              Pulse-chase Biosynthetic Radiolabelling of Pancreatic Islets to Measure Beta Cell Function Paul C. Guest   23.              Rapid and Easy Protocol for Quantification of Next Generation Sequencing Libraries Steve F.C. Hawkins and Paul C. Guest   24.              Telomere length analysis - A Tool for Dissecting Ageing Mechanisms in Developmental Programming Jane L. Tarry-Adkins and Susan E. Ozanne   25.              Qualitative and quantitative NMR Approaches in Blood Serum Lipidomics Banny Silva Barbosa, Lucas Gelain Martins, TássiaB. B. C. Costa, Guilherme Cruz, and LjubicaTasic   26.              In vivo Electrical Stimulation for the Assessment of Skeletal Muscle Contractile Function in Murine Models Kaio F. Vitzel, Marco A. Fortes, Gabriel N. Marzuca-Nassr, Maria V.M. Scervino, Carlos H. Pinheiro, Leonardo R. Silveira, and Rui Curi   27.              Experimental Model of Skeletal Muscle Laceration in Rats Phablo Abreu, Gabriel Nasri Marzuca-Nassr, Sandro Massao Hirabara, and Rui Curi   28.              Neuropsychiatric Sequelae of Early Nutritional Modifications: A Beginner’s Guide to Behavioural Analysis Ann-Katrin Kraeuter, Paul C. Guest, and Zoltán Sarnyai   29.              Hyperlocomotion Test for Assessing Behavioural Disorders Dan Ma and Paul C. Guest   30.              2D-DIGE Analysis of Eye Lens Proteins as a Measure of Cataract Formation Paul C. Guest 31.              Mass Spectrometry Profiling of Pituitary Glands Divya Krishnamurthy, Hassan Rahmoune, and Paul C. Guest   32.              Multiplex Immunoassay Profiling of Hormones Involved in Metabolic Regulation Laurie Stephen and Paul C. Guest   33.              Time Resolved Fluorescence Assays for Quantification of Insulin Precursors in Plasma and Serum Kevin Taylor, Ian Halsall, Paul C. Guest, and Keith Burling   34.              Identification of Neural Stem Cell Biomarkers by Isobaric Tagging for Relative and Ab

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9781493985333
• Collana: Methods in Molecular Biology
• Dimensioni: 254 x 178 mm Ø 1009 gr
• Formato: Brossura
• Illustration Notes: XIV, 520 p. 101 illus., 88 illus. in color.
• Pagine Arabe: 520
• Pagine Romane: xiv