The Deeper Genome

TRAMA

Mapping the human genome proved to be just the beginning in understanding our genes, what makes us human, and how we can use the knowledge to cure inherited diseases. John Parrington describes an emerging picture of our genome, in 3D, with many non-gene players and environmental influences, that is far more complex and subtle than we ever imagined.

NOTE EDITORE

Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

SOMMARIO

1 - The Inheritors 2 - Life as a Code 3 - Switches and Signals 4 - The Spacious Genome 5 - RNA Out of the Shadows 6 - It's a Jungle in There! 7 - The Genome in 3D 8 - The Jumping Genes 9 - The Marks of Lamarck 10 - Code, Non-Code, Garbage, and Junk 11 - Genes and Disease 12 - What Makes us Human? 13 - The Genome That Became Conscious

AUTORE

John Parrington is an Associate Professor in Molecular and Cellular Pharmacology at the University of Oxford, and a Tutorial Fellow in Medicine at Worcester College, Oxford. He has published over 80 peer-reviewed articles in science journals including Nature, Current Biology, Journal of Cell Biology, Journal of Clinical Investigation, The EMBO Journal, Development, Developmental Biology, and Human Reproduction. He has extensive experience writing popular science, having published articles in The Guardian, New Scientist, Chemistry World, and The Biologist. As a British Science Association Media Fellow he has worked as a science journalist at The Times for 7 weeks where he published 22 articles. He has also written science reports for the Wellcome Trust, British Council, and Royal Society.

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9780199688746
• Dimensioni: 194 x 16.2 x 142 mm Ø 202 gr
• Formato: Brossura
• Illustration Notes: 26 black and white illustrations
• Pagine Arabe: 272