Skin 3-D Models and Cosmetics Toxicity

TRAMA

Efforts are being made by research organizations and cosmetic industries worldwide to develop more precise and targeted 3D models that mimic humans for testing cosmetic and personal health care product ingredients, following a complete ban on animal testing. This book includes several subtopics dedicated to the progress made, challenges faced, roadblocks encountered, and future prospects in the development and validation of 3D models for testing these products. The book consist of an editorial and 14 themed chapters that will showcase the significant progress made so far, challenges encountered, and future prospects in the development of 3D reconstruct models.

SOMMARIO

Chapter 1. Editorial: 3D Skin models for cosmetic safety/ toxicity studies: Bridging established methods and novel technologies.- Chapter 2. Artificial skin models for animal-free testing: 3D Skin reconstruct approach, a journey in past two decades.- Chapter 3. Fabrication of ready-to-use ex vivo human skin models for chemical testing: current status and challenges.- Chapter 4. Human skin reconstructs model systems in mechanistic research, safety and efficacy studies of cosmetics: Pros and cons.- Chapter 5. Skin-on-a-Chip Microfluidic Devices: Production, Verification and Uses in Cosmetic Toxicology.- Chapter 6. 3D Bioprinting of skin tissue model.- Chapter 7. Solar radiations and phototoxicity of cosmetics: Avenues of in vitro skin models.- Chapter 8. Cosmetic Ingredients: Various Efficacy-Based testing methods in the 3D Skin based Model Systems.- Chapter 9. Animal component-free medium for long term maintenance of human skin explants and its application in toxicity studies of cosmetics.- Chapter 10. Regulatory requirements for safety/efficacy assessment of cosmetics/nano cosmetics products: Challenges and opportunities.- Chapter 11. Integrated approaches to testing and assessment (IATA) for cosmetic and personal health care products.- Chapter 12. Approach for in-silico validation of safety/ toxicity data for cosmetics.- Chapter 13. Role of omics approaches in the toxicity/ safety studies of cosmetics.- Chapter 14. Application of 3D skin models in safety/ toxicity of fragrances, flavors, hair dyes, preservatives and colorants.- Chapter 15. Toxicokinetic and toxicodynamic studies of cosmetics and personal health care products using 3D skin models: Progress made and path ahead

AUTORE

Professor AB Pant is a seasoned toxicologist with over thirty years of active research career. Presently serving as ‘Senior Principal Scientist’ at CSIR-Indian Institute of Toxicology Research, Lucknow, and also a ‘Professor’ of Academy of Scientific & Innovative Research, an Institution of National Importance set up by the Act of Parliament, Government of India. In the scientific fraternity, Professor Pant is renowned for his elegant research on the application of human stem cells and iPSCs in developmental neurotoxicity and establishing the number of in vitro model systems as an alternative to laboratory animals for biomedical research. He also founded a new discipline of "In-Vitro Toxicology" in the country. He also dedicated himself to fostering contemporary science to Post-Graduate, PhD students, researchers, and university teachers. He is a lead GLP inspector for the Government of India, and also serves as an expert for regulatory bodies, such asBIS, CDSCO, NABL, FSSAI, NGCMA, ICMR, DST, Pharmacovigilance, etc. He has won several awards and honors, including Vigyan Ratna Award-2010 (CST UP); Shakuntala Amir Chand Prize-2007 (ICMR); National Bioscience Award-2012 (DBT); Prof. KT Shetty Memorial Oration Award-2017 (Indian Academy of Neurosciences), Toxicology Promotion Award-2018 (National Academy of Sciences, Allahabad), STOX/ASAW Gold Medal (STOX, India), etc. He has been elected Fellow of Academy of Toxicological Sciences, USA, Society of Toxicology, India, Indian Academy of Neurosciences, Academy of Sciences for Animal Welfare, India, Academy of Environmental Biology India, etc. In view of outstanding credibility in toxicology, Professor Pant has been included as a global toxicologist in the ‘European and United Kingdom Register of Toxicologists’ and has also been conferred the DSc (h. c.) degree by HNB Medical Education University, Dehradun, Uttarakhand, India. He currently serves as Chairman and Member of several National and International Committees/ Boards of Government Institutes and Bodies. He also serves as a member of the editorial board of several reputable journals.  Dr Ashish Dwivedi is graduated from CSIR-Indian Institute of Toxicology Research, Lucknow, India, in the area of Photobiology and Phototoxicology. Thereafter, he enriched himself in the same domain of research as Post-Doctoral Fellow at Israel Institute of Technology, Israel; Colorado University, USA, and Banaras Hindu University, Varanasi, India. Based on his outstanding research experience, he got an opportunity to join back to his parenteral research organization-CSIR-IITR, where he is currently serving as a Scientist in the System Toxicology & Health Risk Assessment Group. In a decade-long research career, Dr Dwivedi has established himself as one among the pioneers in the area of phototoxicity/ photosafety with special reference to the photsafety of therapeutic agents, nanotized phytochemicals, environmental pollutants, etc. Besides the laboratory work, he has also been involved in fostering contemporary science to Post-Graduate, PhD students, researchers, and university teachers. Dr Dwivedi’s research efforts have been rewarding in terms of the quantifiable number of research publications in journals of high repute. He has also edited three books for Springer Nature in the area of Photoprotection, Skin Aging, and Neuroprotection. He is a member of various scientific societies, to name a few are- Society of Toxicology, USA, American Society for Photobiology, USA, Indian Photobiology Society, India, Society of Toxicology, India, etc.    Professor Ratan Singh Ray is a Chief Scientist & Head, Photobiology Division at CSIR-Indian Institute of Toxicology Research, Lucknow, India. He is one of the founders who established a new discipline of Photobiology/ Phototoxicity in the country. His active research career of over three decades in the area of Photobiology made him instrumental as a resource person in the Bureau of Indian Standards for the formulation/ revision of several standards for cosmetics and personal health care products. His research group is credited for creating the complete spectrum of UV-A, UV-B and UV-C radiation falling on the earth's surface at latitude- Longitude 26.8467° N, 80.9462° E for over twenty years. Such dedicated and sustained efforts in creating this database have created immense wealth for the scientific fraternity working in this area of research, industries involved in the production and R & D of cosmetic and personal health care products, and regulatory agencies. He has supervised more than a dozen students for PhD, several post-doctoral fellows and post-graduate students. He is also rendering his intellectual inputs and expertise to various scientific societies and government agencies, such as the Bureau of Indian Standards, India, American Society for Photobiology, USA, Indian Photobiology Society, I

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9789819928033
• Dimensioni: 235 x 155 mm
• Formato: Copertina rigida
• Illustration Notes: XXII, 250 p. 1 illus.
• Pagine Arabe: 250
• Pagine Romane: xxii