Prions and Diseases

TRAMA

Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

SOMMARIO

Part I: HISTORY   Chapter 1   Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek        Paul Brown   Part II: GENERAL ASPECTS OF PRIONS   Chapter 2  The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein                    Glenn L. Millhauser   Chapter 3  Mammalian Prion Structures                    Byron Caughey, Efrosini Artikis, and Allison Kraus   Chapter 4  Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein                    Aggregates in the Brain of Asymptomatic Individuals                    Wen-Quan Zou   Part III: CONVERSION AND STRAIN OF PRIONS   Chapter 5   Prion Conversion and Deformed Templating                     Ilia V. Baskakov   Chapter 6   Prion Strain Interference                         Ronald A. Shikiya and Jason C. Bartz   Chapter 7   Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins              Lenka Hromadkova, M. Khursheed Siddiqi, He Liu, and Jiri G. Safar   Chapter 8   Cofactor Involvement in Prion Propagation                     Surachai Supattapone and Michael B. Miller   Chapter 9    Prion Protein Conversion and Lipids                      Jiyan Ma and Xiangyi Zhang   Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS   Chapter 10  Prions in the Environment                      Shannon L. Bartelt-Hunt, Jason C. Bartz, and Qi Yuan   Chapter 11 Environmentally Acquired Transmissible Spongiform Encephalopathy                     Paul Brown   Chapter 12 Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion              Alexander H. Peden, Marcelo A. Barria   Chapter 13 Species Barriers in Prion Disease                     Suzette A. Priola   Part V:  MODELLING OF PRIONS   Chapter 14 Modeling the Cell Biology of Prions                     Richard Rubenstein, David Doyle and Robert B. Petersen   Chapter 15 Transgenic Mice Modelling in Prion Diseases                     Barry Bradford, Neil A. Mabbott and Abigail B. Diack   Chapter 16 Stem Cell Models in Prion Research                     Cathryn Haigh   Chapter 17 Drosophila Models of Prion Diseases                     Ryan R. Myers and Pedro Fernandez-Funez  Part VI:    HUMAN PRION DISEASES AND OTHER PATHOLOGIES   Chapter 18 Human Sporadic Prion Diseases                     Pierluigi Gambetti and Ignazio Cali   Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases                    James A. Mastrianni   Chapter 20 Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies                     Zerui Wang, Jue Yuan, Tricia Gilliland, Maria Gerasimenko, Syed Zahid Ali Shah, Wen-Quan Zou   Chapter 21 The Spectrum of Tau Pathology in Human Prion Disease                     Gabor G. Kovacs and Herbert Budka   Chapter 22  Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease                     Graham P. Roseman, Li Fu and Stephen M. Strittmatter   Chapter 23 Prion and Cancers              Wei Xin   Chapter 24 Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury                     Zerui Wang and Wen-Quan Zou   Part VII: ANIMAL PRION DISEASES   Chapter 25  Bovine Spongiform Encephalopathy                       Gianluigi Zanusso and Salvatore Monaco   Chapter 26  Classical and Atypical Scrapie in Sheep and Goats                      Christine Fast and Martin H. Groschup   Chapter 27  Research models for studying chronic wasting disease                      Julianna Sun and Glenn Telling   Part VIII: YEAST PRIONS   Chapter 28  Introduction to Yeast and Fungal Prions                      Reed B. Wickner and Herman K. Edskes   Chapter 29  Yeast Prions Are Folded, In-Register Parallel Am

AUTORE

Wen-Quan Zou, MD, PhD is Professor of Pathology at Case Western University School of Medicine, and he is Associate Director of the National Prion Disease Pathology Surveillance Center. Pierluigi Gambetti, MD, is Professor of Pathology and Neurology at Case Western University School of Medicine.

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9783031205675
• Dimensioni: 235 x 155 mm Ø 1217 gr
• Formato: Brossura
• Illustration Notes: XII, 793 p. 81 illus., 62 illus. in color.
• Pagine Arabe: 793
• Pagine Romane: xii