Hormone Resistance and Other Endocrine Paradoxes

TRAMA

Endocrinology and Metabolism: Progress in Research and Clinical Prac­ tice is a new series that has been designed to present timely, critical reviews of constantly evolving fields; to provide practical and up-to-date guidance in the solution of pertinent clinical problems; to offer an alterna­ tive to the laborious search of the literature (and the often frustrating reading of highly technical articles); and to translate the language of the laboratory into that of the practice of medicine. We think that this volume and those to come will prove useful to physi­ cians (and to physicians in training), as well as to investigators in a wide variety of specialties; in short, to anyone who seeks answers to questions in endocrinology and metabolism. The first chapter of this volume could well serve as a general introduc­ tion to the entire series. It points out how our growing understanding of the molecular basis of biologic communication has led to the discovery of a growing number of clinical syndromes, as well as to the realization that phenotypically similar diseases may have radically different pathogenetic mechanisms and thus may require radically different therapeutic strata­ gems.

SOMMARIO

1. Introduction: The Journey of the Endocrine Signal: A Paradigm of Murphy’s Law.- I. Chemical Control of Morphogenesis.- II. Hormone Biosynthesis.- III. Hormone Storage and Release.- IV. Hormone Transport.- V. Hormone Binding and Recognition.- VI. Transduction of the Endocrine Signal.- VII. Extinction of the Endocrine Signal.- VIII. Drug-Induced Changes of the Endocrine Signal.- IX. Summary.- 2. Insulin Gene Mutations and Abnormal Products of the Human Insulin Gene.- I. Insulin Biosynthesis.- II. Abnormal Insulin Gene Products.- III. Structure-Function Relationships and Biological Activity.- IV. Clinical Relevance.- V. Summary and Perspectives.- 3. Euthyroid Hyperthyroxinemia.- I. Binding Abnormalities.- II. Hormone Resistance Syndromes.- III. Nonthyroidal Illness.- IV. Drugs.- V. Exogenous T4 Administration.- VI. High Altitude.- VII. Summary.- 4. Pseudohypoparathyroidism: Target Organ Resistance to Parathyroid Hormone and Other Metabolie Defects.- I. A Selective Historical Review.- II. Classification.- III. Pathogenesis.- IV. Function of Other Endocrine Systems in PsHP.- V. Genetics of PsHP.- VI. Treatment of PsHP.- 5. Syndromes of Vitamin D Resistance.- I. Vitamin D Metabolism.- II. Vitamin D Physiology.- III. Hormone Action.- IV. Vitamin D and Elemental Deficiency.- V. Phosphate-Wasting Syndromes.- VI. Vitamin D—Dependent Rickets.- VII. Summary.- 6. Androgen Insensitivity Syndromes: Paradox of Phenotypic Feminization with Male Genotype and Normal Testicular Androgen Secretion.- I. Historical Considerations.- II. Normal Androgen Physiology.- III. Classification of Male Pseudohermaphroditism.- IV. Molecular Mechanisms of Androgen Action in Target Cells.- V. Clinical Syndrome of 5?-Reductase Deficiency.- VI. Androgen Receptor and Postreceptor Defects.- VII.Concluding Remarks.- 7. States of Aldosterone Deficiency or Pseudodeficiency.- I. Physiologic Effects of Mineralocorticoid Hormones.- II. Syndromes of Aldosterone Deficiency and Pseudodeficiency.- 8. Bartter’s Syndrome.- I. Case Summaries.- II. Historical Perspective.- III. Etiology and Pathophysiology.- IV. Differential Diagnosis.- V. Clinical Evaluation.- VI. Treatment.- VII. Analysis of Cases.

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9781461291435
• Collana: Endocrinology and Metabolism
• Dimensioni: 235 x 155 mm
• Formato: Brossura
• Illustration Notes: XII, 271 p.
• Pagine Arabe: 271
• Pagine Romane: xii