Hippocampal Microcircuits

TRAMA

The hippocampus is thought to play a role in the short-term storage of declarative memories in the human brain. Our understanding of its anatomy, physiology and molecular structure has expanded rapidly in recent years. Yet much still needs to be done to decipher the function of the detailed microcircuits. This overview of our current knowledge of the hippocampus also provides a snapshot of the state of the art of ongoing research into these microcircuits. Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides succinct and focused reviews of experimental results. It is an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject’s experimental background, leading neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Here, ensemble activity, related to behavior, on the part of morphologically identified neurons in anesthetized and freely moving animals, lead to insights into the functions of hippocampal areas. In the second section, on computational analysis, computational neuroscientists present models of hippocampal microcircuits at various levels of detail, including single-cell and network levels. A full chapter is devoted to the single-neuron and network simulation environments currently used by computational neuroscientists in developing their models. In addition to the above, the chapters also identify outstanding questions and areas in need of further clarification that will guide future research by computational neuroscientists.

SOMMARIO

PrefacePart I Experimental Background Connectivity of the Hippocampus Morphology of Hippocampal Neurons Physiological properties of hippocampal neurons Glutamatergic Neurotransmission in the Hippocampus Fast and slow GABAergic transmission in hippocampal circuits Synaptic plasticity at hippocampal synapses – experimental background Neuromodulation of hippocampal cells and circuits Cell Type-Specific Activity during Hippocampal Network Oscillations in Vitro Recording identified neurons in awake and anesthetized rodents Spatial, temporal, and behavioral correlates of hippocampal neuronal activity: A primer for computational analysis Part II Computational Analysis Systematic Data Mining of Hippocampal Synaptic Properties Spatio-Temporal Patterns of Granule Cell Activity Revealed by a Large-Scale, Biologically Realistic Model of the Hippocampal Dentate Gyrus A model of spatial reach in LFP recordings Models of Rate and Phase Coding of Place Cells in Hippocampal Microcircuits A model for grid firing and theta-nested gamma oscillations in layer 2 of the medial entorhinal cortex Computational Models of Grid Cell Firing Modeling synaptic plasticity in hippocampus: a calcium-based approach Simplified Compartmental Models of CA1 Pyramidal Cells of Theta-Modulated Inhibition Effects on Spike Timing-Dependent Plasticity Factors affecting STDP in the dendrites of CA1 pyramidal cells Computational examination of synaptic plasticity and metaplasticity in hippocampal dentate granule neurons Genome-wide associations of schizophrenia studied with computer simulation MODELLING EPILEPTIC ACTIVITY IN HIPPOCAMPAL CA3 A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus Resources for Modeling in Computational Neuroscience Experiment-modelling cycling with populations  of  multi-compartment  models: application  to  hippocampal  interneurons Index  

AUTORE

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9783319991023
• Collana: Springer Series in Computational Neuroscience
• Dimensioni: 235 x 155 mm Ø 1935 gr
• Formato: Copertina rigida
• Illustration Notes: XVII, 885 p. 182 illus., 120 illus. in color.
• Pagine Arabe: 885
• Pagine Romane: xvii