Handbook of Oncobiology: From Basic to Clinical Sciences

TRAMA

This Handbook on cancer biology comprehensively reviews the current status of the oncobiology of major cancer types, cancer detection and treatment strategies, principles and processes of cancer drug development, and nanomedicine and other emerging cancer medicine applications to cancer diagnosis and treatment.  The book also provides practical and implementable nutritional guidance in cancer prevention, treatment, and quality of life for cancer survivors. It discusses pharmacogenetics strategies for predicting cancer prognosis and treatment exposure, response, and toxicity. Further, it presents bioinformatics approaches for predicting anti-cancer drugs and drug combinations based on the multi-omic data, including transcriptomics, toxicogenomics, functional genomics, and biological networks. The Handbook also examines major factors and pathways that regulate cancer stem cells development and discusses potential targeted therapy for cancer stem cells. The book explores the application of the CRISPR/Cas9-based gene-editing technique in basic cancer research, diagnosis, and treatment of cancer. This Handbook is an invaluable source for oncologists, researchers, public health specialists, epidemiologists, and policy makers.

SOMMARIO

Current Concepts and Advances in Oncobiology.- History, Evolution, Milestones in Cancer Research and Treatment.- Cancer Statistics: Geographical and Racial Disparities.- A Comprehensive Overview of Various Cancer Types and Their Progression.- Strategies of Early Diagnosis of Cancers.- Advancement in Cancer Modeling System: Latest Developments and Trends in Cancer Research and Healthcare Interventions.- Point of Care Molecular Diagnostics in Cancer.- Genetics of Cancer: Past, Present and Future.- Mechanisms of Oncogenesis.- Recent Developments in Cancer Detection and Treatment.- Circadian Rhythms and Their Association with Cancer Development.- Advances in Cancer Pain Management.- Genetic Alterations and Microbial Dysbiosis Underlie Lymph Node Metastasis in Tongue Cancer.- Skin Cancer: An Overview.- Squamous Cell Carcinoma Predisposition Pathophysiology, Diagnosis, and Treatment.- Tumor Heterogeneity in Breast Cancer Progression.- Molecular Pathways in Breast Cancer Chemoresistance.- Therapeutic Efficacy of Estrogen Related Receptor ß in Breast Carcinoma.- Diagnostic-Prognostic Biomarkers and Their Clinical Implication in Breast Cancer.- Tumour Inflammatory Microenvironment in Lung Cancer: Heterogeneity and Implications.- Brain Tumors: Types, Diagnostic Biomarkers and New Therapeutic Approaches.- Current Pathophysiology, Treatment, and Future Perspective for Prostate Cancer.- Emerging Pathophysiology and Treatment Prostate Cancer: Future Perspective.- Androgen Receptor Signaling: a Central and Evolving Theme in Prostate Cancer Treatment.- Structuring Inflammasome-Epigenome – Phenotypic Axis in Gynecological Cancers.

AUTORE

Professor R C Sobti, Senior Scientist (Indian National Science Academy), Former Vice Chancellor, Babasaheb Bhimrao Ambedkar University, Lucknow (UP) and Panjab University, Chandigarh, Former Education, Advisor, Governor of Bihar is, indeed, a polymath--a renowned academician, distinguished scientist, dynamic administrator and a visionary gifted with an immensely optimistic disposition and integrity of character, words and action. He has also been member of the EC of Society of Indian Institute of Mass Communication, India (2013-16), Chairman Governing Council, National Council of Science Museum (2014-2018) as well as member of various committees of UGC, DBT, CSIR, DRDO and NAAC. He was general president Indian Science Congress Association (2013-2014).Starting his career as a Cytogeneticist worked the animal molecular biology to look for solution to intricate problems of animal systems. Professor Sobti has been proactively involved in cancer biology and focused on finding out novel tumour markers of diagnostics and cancer prognostic importance for cancer. He evaluated the role of gene polymorphisms and their expression in the genesis of various cancers, COPD, AIDS and metabolic syndrome. The identification of disease susceptible /protective novel genotypes and determination of the crucial role of SACS-1 and STAT genes in the genesis of cervical and prostate cancers are the most noteworthy observations.  He has recently identified certain Hub genes of diagnostic importance in uterine cancers, besides working on the importance of genes in development of animals as well as the role of certain rare plants on anti microbes.His immense contributions to science includes, inter alia, 350 plus high impact research publications 55 books especially the ones on Translational Research in Biomedical Sciences and various aspects of Covid 19 (6 books) under INSA Senior Scientist Programme published by international publishers like Springer Nature, Elsevier, CRC, Cambridge Scholar. He has also published more than 35 chapters in these books. He has successfully handled 23 Sponsored Research Projects and supervised more than 50 students for the Ph.D, M.Sc., M.Phil and a D.Sc. degrees.He has delivered numerous keynote addresses at reputed National and International forums, based on implications and applications of science and scientific temper for general awareness and improvements of everyday life and lifestyle in a lucid and people-centric manner.Professor Sobti is a Fellow of the Third World Academy of Sciences (TWAS), National Academy of Sciences, Indian National Science Academy, National Academies of Medical Sciences and Agricultural Sciences and Canadian Academy of Cardiovascular Diseases. He is also associated with many other Academic Associations and Institutions in the domain of higher education and research. The litany of honours showered on him includes, among others, the INSA Young Scientist Medal (1978), UGC Career Research Award, Punjab Rattan Award, JC Bose Oration Award and the Life Time Achievement Award of the Punjab Academy of Sciences, Zoological Society of India, and the Environment academy of India, besides many other medals & awards of various reputed National and International Organizations. He has visited UK, Japan, Germany under exchange programme of those countries with INSA, UGC etc.In recognition of his enormous contributions to higher education, he has been bestowed with a large number of prestigious awards and medals which adorn his academic and professional career. The Government of India bestowed upon him the honour of “PADMASHRI” in 2009 by way of rightfully acknowledging his great contribution to higher education in India. On 2nd July, 2016, he was also honoured with ‘Bharat Gaurav’, Life Time Achievement Award at the House of Commons, British Parliament, London, U. K.Professor Sobti, not only excels in creating academic atmosphere, but is also equally steadfast and loyal towards environment and society. His charismatic aura and unrelenting attitude, that does encourage and motivate all, has an inherent capacity of transforming the organisation into a synergistic, cohesive and vibrant team.Professor Sobti’s pragmatic approach and dynamic vision encapsulated in his view that education in University should be a mechanism for social change and liberating force for the individual and the society, resulted in initiating various Community Engagement Programmes. His innovative ideas in enthusing the faculty and students to excel in research and academics and his efforts in transferring these ideas to the needy through scientific spirit and temper can be pronounced as distinct and exceptional. Professor Sobti has not only instilled the importance of science and scientific perspective in the personal and societal development, but has also rigorouslycampa

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9789819962624
• Dimensioni: 235 x 155 mm
• Formato: Copertina rigida
• Illustration Notes: XLVIII, 1578 p. 225 illus., 208 illus. in color. In 2 volumes, not available separately.
• Pagine Arabe: 1578
• Pagine Romane: xlviii