Genome Editing in Neurosciences

TRAMA

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

SOMMARIO

Introduction.- In vitro modeling of complex neurological diseases.- Aquatic model organisms in neurosciences : the genome editing revolution.- Genome-wide genetic screening in the mammalian CNS.- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish.- Dissecting the role of synaptic proteins with CRISPR.- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer.- Neuroscience research using non-human primate models and genome editing.- Multiscale genome engineering: Genome-wide screens and targeted approaches.- Using Genome Engineering to Understand Huntington’s Disease.- Therapeutic gene editing in muscles and muscle stem cells.

AUTORE

Rudolf Jaenisch, MIT Cambridge, USAFeng Zhang, MIT Cambridge, USAFred Gage, Salk Institute for Biological Studies, La Jolla, CA, USA

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9783319601915
• Collana: Research and Perspectives in Neurosciences
• Dimensioni: 235 x 155 mm Ø 3317 gr
• Formato: Copertina rigida
• Illustration Notes: XI, 123 p. 16 illus. in color.
• Pagine Arabe: 123
• Pagine Romane: xi