Epidemiology and Control of Neural Tube Defects

NOTE EDITORE

Neural tube defects, spina bifida, anencephalus, and encephalocoele, are among the commonest severe congenital abnormalities in most countries. The last decade has seen many advances, including the use of antenatal diagnosis by chemical and ultrasound methods, population screening, and many new findings in epidemiology, culminating in the demonstration of the protective effect of folic acid on recurrences. The progress in both antenatal diagnosis and in aetiological research on neural tube defects has been particularly dramatic, and may well anticipate developments in regard to other congenital abnormalities. Primary prevention now appears as an attainable goal. This book presents a critical review of the extensive findings of epidemiological studies, discusses several methodological issues of wider relevance such as ascertainment, seasonal variation, ethical and legal issues. As well as providing a unique resource in regard to neural tube defects, much of the material is relevant to those with wider interests in the prevention, antenatal diagnosis, and control of major diseases.

SOMMARIO

1 - An historical perspective2 - Classification, anatomy, and embryology3 - Ascertainment, registration, and assessment of exposure4 - Geographical variation5 - Ethnic origin and migration6 - Secular trends7 - Seasonal variation8 - Clustering in time and space9 - Distribution10 - Early fetal loss11 - Associations with multiple pregnancy12 - Maternal age and reproductive history13 - Maternal illness and drug use in pregnancy14 - Socio-economic status and occupation15 - Diet16 - Risks in siblings and other relatives17 - Genetic models18 - Antenatal screening and diagnosis19 - Ethical and legal issues20 - Conclusions

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9780192618849
• Collana: Monographs in Epidemiology and Biostatistics
• Dimensioni: 234 x 156 mm Ø 1394 gr
• Formato: Copertina rigida
• Illustration Notes: line drawings, tables
• Pagine Arabe: 944