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Libro
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- Genere: Libro
- Lingua: Inglese
- Editore: Informa Healthcare
- Pubblicazione: 09/2003
- Edizione: 1° edizione
Drug Metabolizing Enzymes
lee jae (curatore); obach r. scott (curatore); fisher michael b. (curatore)
234,98 €
223,23 €
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TRAMA
Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes - as well as parallel issues shaping the pharmaceutical industry - to promote the next generation of safer, more effective drugs.SOMMARIO
Dioxygen activation by cytochromes P450 - a role for multiple oxidants in the oxidation of substrates, Alfin D.N. Vaz; application of LC/MS, LC/NMR, NMR and stable isotopes in identifying and characterizing metabolites, A.E. Mutlib and John P. Shockcor; bioactivation, Jack Uetrecht; chemically reactive metabolites in drug discovery and development, Thomas A. Baillie; cytochrome P450 and its place in drug discovery and development, Dennis Smith; cytochrome P450 in laboratory animal species, Margit Spatzenegger, Stephanie L. Born and James R. Halpert; typical and atypical enzyme, Kinetics J. Brian Houston, Kathryn E. Kenworthy and Aleksandra Galetin; cytochrome P450 reaction phenotyping, Larry C. Wienkers and Jeffrey C. Stevens; drug-drug interactions and the cytochromes P450, Kenneth A. Bachmann, Barbara J. Ring and Steven A. Wrighton; CYP gene induction by xenobiotics and drugs, Jean-Marc Pascussi, Sabine Gerbal-Chaloin, Martine Daujat, Lionel Drocourt, Lydiane Pichard-Garcia, Marie-Jose Vilarem, Patrick Maurel, Sylvie Klieber, Francois Torreilles, Martine Bourrie, Francois Guillou and Gerard Fabre; cytochrome P450 pharmacogenetics, Robert L. Haining and Aiming Yu; role of intestinal cytochromes P450 in drug deposition, Mary F. Paine and Kenneth E. Thummel; prediction of hepatic clearance in humans from experimental animals and in vitro data, Masato Chiba, Yoshihiro Shibata, Hiroyuki Takahashi, Yasuyuki Ishii and Yuichi Sugiyama; non-P450 mediated oxidative metabolism of xenobiotics, Dieter Lang and Amit S. Kalgutkar; the role of sulfotransferases (SULTs) and UDP-glucuronosyltransferases (UGTs) in human drug clearance and bioactivation, Michael W.H. Coughtrie and Michael B. Fisher.ALTRE INFORMAZIONI
- Condizione: Nuovo
- ISBN: 9780824742935
- Dimensioni: 9.25 x 6.25 in Ø 2.40 lb
- Formato: Copertina rigida
- Pagine Arabe: 608