Carbocation Chemistry

NOTE EDITORE

Carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organic chemistry. Carbocation Chemistry: Applications in Organic Synthesis provides a panoramic view of carbocation chemistry with an emphasis on synthetic applications. This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.

SOMMARIO

Chapter 1. Introduction Nomenclature, Structure, and Stability Generation of Carbocations The Non-Classical Ion Controversy Electrophilic Addition to Alkenes Electrophilic Aromatic Substitution Elimination reactions Rearrangement Reactions of Carbocations References Chapter 2. Nucleophilic Aliphatic Substitution – SN1 Introduction -Activated Alcohols—Brønsted Acids -Activated Alcohols—Lewis Acids Alkylation of Aldehydes and Ketones Glycosylation Friedel–Crafts Alkylation and Acylation Electrophilic Fluorination Using Fluoronium Ion Miscellaneous SN1-related Reactions References Chapter 3. Nucleophilic Aliphatic Substitution – SN2 Construction of Quaternary Stereogenic Centers Sulfur Chemistry Organometallic Chemistry Macrocyclization Glycosylation Nucleoside Analogues N-Alkylation Cyclotetraphosphazenes Conformationally Locked Tetrahydropyran Ring The Ionic Liquid Effect Silver Chemistry References Chapter 4. Electrophilic Addition to Alkenes Introduction Cyclopropanation Hydroboration/Oxidation The Pauson–Khand Reaction Prins Reaction Schmidt Reaction Halogenation Oxymercuration/Reduction Epoxidation Gold-Catalyzed Alkyne Hydration Conclusion References Chapter 5. Electrophilic Aromatic Substitution Introduction Nitration Halogenation Friedel–Crafts Alkylation Friedel–Crafts Acylation Applications of Friedel–Crafts Reaction on Total Synthesis Miscellaneous Electrophilic Aromatic Substitution Reactions References Chapter 6. Fragmentation and Rearrangement Reactions Claisen Rearrangements Cope Rearrangements Cope Rearrangements Aldehyde (or Ketone) Formation Rearrangements Carboxylic Acid Formation Rearrangements Alcohol Formation Rearrangements Amine Formation Rearrangement Amides Hydrocarbon Rearrangements Oxacyclic, Carbocyclic, Oxazoles, Tetrahydrapuran and Tetrahydropuran Formation Rearrangements Rearrangements resulting in less common functional groups Fragmentations References

AUTORE

Jie Jack Li earned his Ph.D. in organic chemistry in 1995 at Indiana University. After a stint as a postdoctoral fellow at MIT, he worked as a medicinal chemist at Pfizer and Bristol-Myers Squibb from 1997 to 2012. Since then he has been an Associate Professor of Chemistry at the University of San Francisco teaching organic and medicinal chemistry. He has published 23 books ranging from organic and medicinal chemistry, to the history of drug discovery.

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9781498729086
• Collana: New Directions in Organic & Biological Chemistry
• Dimensioni: 9.25 x 6.25 in Ø 0.99 lb
• Formato: Copertina rigida
• Illustration Notes: 379 b/w images
• Pagine Arabe: 208
• Pagine Romane: xiv